Ahus Gastrointestinal Radiology (Gastrorad) Research Group

Ahus Gastrointestinal Radiology (Gastrorad) Research Group
Akershus University Hospital and University of Oslo

The GASTRORAD research group focuses on imaging of Abdominal and Gastrointestinal diseases, both inflammatory and malignant. We investigate diagnostic accuracy and reproducibility as well as the predictive importance of imaging features.

We contribute to the Oxy-Target project looking at patients with rectal cancer through evaluation of the morphological features of the cancer and comparing these morphological findings with functional MRI measurements and clinical and molecular data.  We are investigating the use of a new, advanced hybrid MRI technique for the imaging of cancer. The method combines two MRI sequences: a morphologic T2* weighted series and a rapid contrast enhanced series to acquire tumour perfusion. The parameters may improve the phenotyping of tumour tissue and indicate the degree of aggressiveness and growth potential.

The Metimmox study investigates the use of immune therapy in patients with advanced colorectal disease. In this study we provide a centralized iRecist evaluation of the included patients. These patients have advanced disease with liver metastases and their treatment response is evaluated with repeated Computer Tomography (CT) of the lungs and abdomen.

Our research group is also running a multi-centre project, The IBSEN III study, on MR imaging of Crohn’s disease, an inflammatory bowel disease. We perform MRI of the bowel with morphological and functional imaging sequences at baseline and we will investigate if the degree of increased bowel wall thickness or other MRI measurements of inflammatory activity, can predict disease course and/or treatment response. The included patients will be followed longitudinally for at least 5 years and the study is developed based on experiences from the earlier IBSEN I study.

 

 

 

Recent Publications List (Link)
Anne Negård, MD, PhD

Position: Group Leader, Head of Section and Consultant Abdominal Radiologist, Department of Radiology , Akershus University Hospital and Associate Professor, Institute of Clinical Medicine, Campus Ahus, University of Oslo.

Research interest: MRI and CT of inflammatory and malignant disease with evaluation of diagnostic accuracy and reproducibility. Prognostic potential of different imaging features to predict treatment response and a favorable disease course.
Aida Kapic Lunder, MD, PhD

Position: Resident and Research Fellow at the Department of Radiology, Akershus University Hospital

Research interest: MRI of bowel inflammation and extra-intestinal manifestations in IBD. MRI and CT of colorectal cancer.
Elin Agathe Frøyen, MD

Position: Consultant Abdominal Radiologist, Section of Abdominal, Oncology and Childrens Radiology, Akershus University Hospital

Research interest: MRI and the evaluation of extramural venous tumour invasion in rectal cancer. Predictive power of morphological MRI features compared to functional MRI parameters and other clinical and molecular factors. The use of structured feedback in the learning process of staging rectal cancer. Participate in the Metimmox study with the evaluation of the CT examinations.
Stein Harald Holmedal, MD

Position: Consultant Abdominal Radiologist and Head of Abdominal, Oncology and Children's Radiology, Department of Radiology, Akershus University Hospital.

Research interest: MRI and CT of gastrointestinal malignancy. Participate in the Oxytarget study and the Metimmox study with evaluation of the MRI and CT examinations.
Linda Tøften Bakstad, MD

Position: Consultant Abdominal Radiologist, Department of Radiology, Akershus University Hospital.

Research interest: MRI of bowel inflammation. Participate in the Ibsen study with evaluation of the MRI examinations .
Tom Jørgen Johansen, MD

Position: Consultant Abdominal Radiologist, Department of Radiology, Akershus University Hospital.

Research interest: MRI and CT of colorectal cancer . Participate in the Oxytarget study with evaluation of the Rectal MRI .

 

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